安 艳

发布时间:2016-01-13  浏览次数:938




安艳


姓名:安艳(1969.09-),女,回族,辽宁省营口市人; 职称:研究员、博士生导师(个人主页:http://web.suda.edu.cn/annine/recruit.html


1.学历

2002.04–2005.03 日本大学药学部                       博士研究生

1998.09–2001.07 吉林大学白求恩医学院                 博士研究生

1993.09–1996.07 中国辐射防护研究院环境医学研究所     硕士研究生

1988.09–1993.07 山西医学院预防医学系                 大学本科


2.工作经历和任职

2008.07–至今     苏州大学医学部公共卫生学院

研究员 (2008.07起博导)

2005.04–2008.06  山东省医学科学院放射医学研究所

研究员 (2005.07起硕导)

2002.04–2005.03  日本大学药学部

日本文部科学省资助国费留学生

2000.09–2002.03  日本大学药学部

外国人研究员

1998.09–1998.12  日本国放射线医学综合研究所

日本科技厅科技交流访问学者

1996.08–2005.03  中国辐射防护研究院环境医学研究所

助理研究员


3.研究方向

环境毒理学和职业毒理学


  1. 在研课题

12016.01-2019.12国家自然科学基金面上项目“砷致细胞恶性转化过程中转录因子Nrf2的作用及调控机制(No.81573173)”,在研,主持;

22018.04-2020.12国家自然科学基金国际(地区)合作交流项目(与日本学术振兴会NSFC—JSPS)“砷致细胞恶性转化过程中二甲基化胂对转录因子Nrf2的作用研究(No.8171101410)”,在研,主持。


5.发表论文和科研获奖情况

Free Radical Biology and MedicineToxicology and Applied PharmacologyCancer Lett、《中华地方病学杂志》等国内、外专业学术期刊上以第一作者或通讯作者发表论文110余篇;为首荣获核工业部科学技术进步三等奖、省科技进步三等奖以及山东省第八届青年科技奖等省、部级各级奖项15项;主编和参编著作4部,申请国家发明专利1项;担任Toxicology Research、《中华地方病学杂志》等多家杂志的编委及审稿专家。

3发表论文(通讯作者)

1Dapeng Wang; Yasuyo Shimoda; Sanxiang Wang,; Zhenghui Wang; Jian Liu; Xing Liu; Huanyu Jin; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Jie Zhang; Yan An. Total Arsenic and Speciation Analysis of Saliva and Urine Samples from Individuals Living in Chronic Arsenicosis Area in China. Environmental Health and Preventive Medicine.2017, 22:45.

DOI: 10.1186/s12199-017-0652-5.

2Hengdong ZhangMing XuQiuni ZhaoKai SunWei GongQiaoyun ZhangBaoli ZhuYan An. Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population. International Journal of Environmental Research and Public Health. 2017, 14, 36.

DOI:10.3390/ijerph14010036.

3Xing Liu; Bin Sun; Xiaojuan Wang; Jihua Nie; Zhihai Chen; Yan An; Jian Tong. Synergistic Effect of Radon and Sodium Arsenite on DNA Damage in HBE Cells. Environmental Toxicology and Pharmacology. 2016. 41:127-131.

DOI: 10.1016/j.etap.2015.11.013

4Xu Yang; Dapeng Wang; Yuan Ma; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka;Yan An. Continuous Activation of Nrf2 and Its Target Antioxidant Enzymes Leads to Arsenite-Induced Malignant Transformation of Human Bronchial Epithelial Cells. Toxicology and Applied Pharmacology. 2015. 289231-239

DOI: 10.1016/j.taap.2015.09.020

5Dapeng Wang; Yuan Ma; Xu Yang; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Yan An.Hypermethylation of Keap1 Gene Inactivates Its Function and Promotes Nrf2 Nuclear Accumulation Is Involved in Arsenite-Induced Human Keratinocyte Transformation. Free Radical Biology and Medicine. 2015.89209-219.

DOI10.1016/j.freeradbiomed.2015.07.153

6Dapeng Wang; Yasuyo Shimoda; Hidetoshi Kurosawa; Jian Liu; Xiguo Xu; Xing Liu; Huanyu Jin; Jian Tong; Kenzo Yamanaka; Yan An. Excretion Patterns of Arsenic and Its Metabolites in Human Saliva and Urine After Ingestion of Chinese Seaweed. International Journal of Environmental Analytical Chemistry. 2015. 95(5): 379-389.

DOI: 10.1080/03067319.2015.10368608

7Zhen Zhu, Hua Yin, Yan An. Antioxidant Activity of Silk Fibroin Peptide Hydrolyzed by Pancreatin. Advanced Materials Research. 20151081110-114(EI).

8Zhen Zhu; Dapeng Wang; Yuan Ma; Xu Yang; Xiaojuan Wang; Hua Yin; Yan An. Optimization of Antioxidant Silk Fibroin Peptide Hydrolysis Process. Advanced Materials Research. 20151073-10761789-1792(EI).

9)国家发明专利:安艳;王小娟;倪一平. 不同线粒体DNA数目人角质形成细胞株的建立和鉴定技术【专利(申请)号:201610454295.9;申请公告号:CN106119205 A

10)实用新型专利:安艳;倪一平. 条带切割装置【专利申请号2018201134810.

11)实用新型专利:安艳;倪一平. 一种用于涂覆蛋白条带的盒【专利申请号:2018201299739.

13)主编:《国家污染物环境健康风险名录.生物分册》,中国环境出版社,201312月第一次印刷(36万字,ISBN 978-7-5111-1678-9.

14)参编:《现代环境毒理学》,中国环境出版社,201512月第一版(ISBN 978-7-5111-2381-7 .

15)参编:《毒理学基础》,人民卫生出版社,2017年第七版(ISBN 978-7-117-24633-0/R•24634.

16)参编:《环境毒理学基础》,人民卫生出版社,2018年第三版.


获奖情况:

  1. 山东省科学技术进步三等奖(排名1/10)(2011

  2. 第五届亚洲毒理学研讨会优秀墙报奖(排名1/8)(2009

  3. 山东省第八届青年科技奖(2008

  4. 中国毒理学会首届全国优秀青年科技人才奖(2007

  5. 国防科学技术二等奖(排名14/42)(2002

  6. 环境保护科技成果奖(排名14/42)2001

  7. 中国核工业总公司科学技术进步三等奖(排名1/8(1997

  8. 山西省科学技术协会优秀论文三等奖(排名1/10(1997

  9. 山西省首届青年论文大赛优秀论文二等奖(1/8)1996


6.教学工作

承担教学任务

  1. 公共卫生学院硕士研究生基础课程《卫生毒理学》

  2. 公共卫生学院硕士研究生基础课程《高级毒理学》

  3. 预防医学专业课《卫生毒理学》(双语和全英文教学)

  4. 全校公共选修课《环境与健康同行》

  5. 全校公共选修课《纳米世界》

  6. 全校公共选修课《临床毒理学》

  7. 新生研讨课《环境污染与健康》

  8. 新生研讨课《纳米世界漫谈》

  9. 新生研讨课《由毒至药:砷的两面性》


7.社会工作

  1. 教育部科研基金和科技奖励评审专家

  2. 教育部留学回国人员科研启动基金评审专家

  3. 科技部国际科技合作计划评审专家

  4. 中国博士后基金评审专家

  5. 山东省科技攻关计划项目评审专家

  6. 山东省科学技术奖励评审专家

  7. 山东省医药卫生科技计划项目评审专家

  8. 天津市、重庆市自然科学基金评审专家

  9. 浙江省、广东省自然科学基金评审专家

  10. 中国环境诱变剂学会活性氧生物学效应专业委员会  委员

  11. 中国生物物理学会自由基生物学与自由基医学分会  理事

  12. 中国中西医结合学会时间生物学专业委员会        委员

  13. 江苏省毒理学会基础毒理学专业委员会            副主任委员

  14. 江苏省毒理学会                                理事

  15. 《国外医学 医学地理学分册》                   常务编委

  16. 《中华地方病学杂志》                          编委

  17. Toxicology Research                           审稿人


8.联系方式


联系电话:0512-65880910(办)          邮箱:annine@suda.edu.cn

18550298429(手机)               dranyan@126.com


CURRICULUM VITAE

Yan An

Mar. 2018


GENERAL


Contact Information


Dr. Yan An


Department of Toxicology

School of Public Health

Medical College of Soochow University

199 Renai RdSuzhou Industrial Park

Suzhou 215123Jiangsu ProvinceChina

Tel: (+86)512-65880910(O)

(+86)18550298429(M)

E-mail: dranyan@126.com

annine@suda.edu.cn


Education


2005

PhD

Environmental Toxicology

Nihon University College of Pharmacy

With Prof. Kenzo Yamanaka

2001

PhD

Radiomedicine

Jilin University Norman Bethune Medical College

with Prof. Zenglin Gao

1996

MS

Industrial Hygiene

and Occupational Diseases

China Institute for Radiation Protection

With Prof. Rusong Chen

1993

B.S.Med

Preventive Medicine

Shanxi Medical University






Positions


2008-

Professor

Department of Toxicology

School of Public Health Medical College of Soochow University

2005-08

Professor

Department of Radiation Effects, Institute for Radiation Medicine,

Shandong Academy of Medical Sciences

1996-2005

Research

Assistant Professor

Department of Life Science China Institute for Radiation Protection




Honors and awards


2011

Third Prize for The study on Carcinogenic Mechanisms of Arsenics- Metabolic methylation of arsenic-induced oxidative stress

Science & Technology Advancement Award of Shandong province

2009

Poster award for A case-control study on         relationship between arsenic in drinking water and skin lesions in endemic arsenism area of Shanxi province, China

The 5th International Congress of Asia Society of ToxicologyASIATOX-V

2008


The introduction of a shortage talents of high-level personnel funded projects in Suzhou city

2008

The 8th Youth of Sciences & Technology award of Shandong provience,

2011

The National Outstanding Youth Scientists and Technicians Award for Carcinogenic Mechanisms of Arsenics- Metabolic methylation of arsenic-induced oxidative stress

The 2nd Session of National Chinese Youth Scholar Science and Technology Forum of Chinese Society of ToxicologyCST

2005

Import of foreign talent in Shandong province

Human Resources and Social Security Department of Shandong province

2000-

2005


Japanese Government (MONBUKAGAKUSHO: MEXT) Scholarship

2002

The 2nd class award for The Study on Judging Criterion of Public Nuisance Disease

National Defense Sciences & Technology Award,

2001

Excellent achievement award on Judging Criterion of Public Nuisance Disease

State Environmental Protection Administration of China

1999

The 3rd class award for The Morphometric Study of 131I-Induced Injury in Rat Thyroid

The 10th Conference of Shanxi Science & Technology

1999

Excellent achievement award on Carcinogenesis of Arsenic

The Organizing Committee of International Cooperative Symposium for Global Telemedicine Exchange of Excellent Studies on Oriental & Occidental Medicine,

1999

Awarded a grade of International Certificate of Excellent Papers forthe study on TheRetentionPatternof Radioiodine inRatThyroid and itsDoseEvaluation

World Network of Traditional Chinese Medicine U.K.

1998

The 2nd class awardfor The study on The Retention Pattern of Radioiodine in Rat Thyroid and its Dose Evaluation

The 2nd Development Conference of Sciences & Technology of Huazhong Area

1998

The 3rdclass award for The study onThe MorphometricStudy of 131I-Induced Injury inRatThyroid

Science & Technology Advancement Award of Ministry of Nucleus Industry of China

1996

The 2nd class award for The study onTheRetentionPattern of Radioiodine in RatThyroidand itsDose Evaluation

The 1st Conference of the Youth of Sciences & Technology of Shanxi


INTERNATIONAL EXPERIENCE


Oct. 2000-Mar. 2005 Department of Environmental Toxicology and Carcinogenesis, Nihon University College of Pharmacy, Japan.

Research student of Graduate School of Nihon University as a Japanese Government (MONBUSHO) Scholarship student

Sept. 1998-Dec. 1998 National Institute of Radiation Sciences, Japan

Japan Science & TechnologyAgency Scientist Exchange Program


RESEARCH


External competitive grants as PI

I have received grants from the following funding sources:


1.  2016.01-2019.12 Natural Science Foundation of ChinaNSFC)“Regulative role of transcription factor Nrf2 in arsenic-induced human keratinocytes transformationNo.81573173)”);

2.  2018.04-2020.12 Natural Science Foundation of Chinaof International Cooperation and ExchangesNSFC—JSPS)“Investigating the Effect of Dimethylated Arsenic Species on Nrf2 in Arsenic-induced Human Keratinocytes TransformationNo.8171101410)”).



Publication list


ISI Researcher ID: http://www.researcherid.com/rid/K-8337-2016


Papers in ISI indexed journals (corresponding author)


Year 2017


27. Hengdong Zhang, Ming Xu, Qiuni Zhao, Kai Sun, Wei Gong, Qiaoyun Zhang, Baoli Zhu, Yan An. Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population. International Journal of Environmental Research and Public Health.2017, 14, 36.

DOI:10.3390/ijerph14010036

26. Dapeng Wang; Yasuyo Shimoda; Sanxiang Wang; Zhenghui Wang; Jian Liu; Xing Liu; Huanyu Jin; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Jie Zhang; Yan An. Total Arsenic and Speciation Analysis of Saliva and Urine Samples from Individuals Living in Chronic Arsenicosis Area in China. Environmental Health and Preventive Medicine.2017, 22:45.

DOI: 10.1186/s12199-017-0652-5


Before 2017


25. Xing Liu; Bin Sun; Xiaojuan Wang; Jihua Nie; Zhihai Chen; Yan An; Jian Tong. Synergistic Effect of Radon and Sodium Arsenite on DNA Damage in HBE Cells. Environmental Toxicology and Pharmacology. 2016,41: 127-131.

DOI: 10.1016/j.etap.2015.11.013

24. Dapeng Wang; Yuan Ma; Xu Yang; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Yan An. Hypermethylation of Keap1 Gene Inactivates Its Function and Promotes Nrf2 Nuclear Accumulation Is Involved in Arsenite-Induced Human Keratinocyte Transformation. Free Radical Biology and Medicine.2015,89:209-219.

DOI10.1016/j.freeradbiomed.2015.07.153

23. Xu Yang; Dapeng Wang; Yuan Ma; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Yan An. Continuous Activation of Nrf2 and Its Target Antioxidant Enzymes Leads to Arsenite-Induced Malignant Transformation of Human Bronchial Epithelial Cells. Toxicology and Applied Pharmacology. 2015, 289:231-239.

DOI: 10.1016/j.taap.2015.09.020

22. Zhen Zhu, Dapeng Wang,Yuan Ma, Xu Yang, Xiaojuan Wang, Hua Yin, Yan An. Optimization of antioxidant silk fibroin peptide hydrolysis process. Advanced Materials Research. 2015,1073-1076:1789-1792(EI).

21. Zhen Zhu, Hua Yin, Yan An. Antioxidant activity of silk fibroin peptide hydrolyzed by pancreatin. Advanced Materials Research. 2015,1081:110-114(EI).

20. Dapeng Wang, Yasuyo Shimoda, Hidetoshi Kurosawa, Jian Liu, Xiguo Xu, Xing Liu, Huanyu Jin, Jian Tong, Kenzo Yamanaka, Yan An. Excretion Patterns of Arsenic and Its Metabolites in Human Saliva and Urine After Ingestion of Chinese Seaweed. International Journal of Environmental Analytical Chemistry. 2015, 95(5):379-389.

DOI: 10.1080/03067319.2015.10368608

19. Huanyu Jin, Xing Liu, Hua Yin, Yan An. The application of silk fibroin in tissue engineering and drug carrier area. Advanced Materials Research. 2013,634-6381120-1123(EI).

18. Huanyu Jin, Hua Yin, Yan An. The effect of gamma ray on the thermo-mechanical property of silk fibroin. Thermal Science. 2013, 17(5): 1521-1522.

DOI: 102298/TSCI1305521J#

17. Huanyu Jin, Yu Liu, Xing Liu, Dapeng Wang, Jian Liu, Hua Yin, Yan An. Study on biocompatibility of post-irradiated silk fibroin in vitro. Advanced Materials Research. 2012,535-537:2357-2360(EI).

16. Huanyu Jin, Yu Liu, Xing Liu, Dapeng Wang, Jian Liu,Hemei Zhang, Chunyan Zong, Hua Zhao, Xiaoqing Feng, Hua Yin, Yan An. Effect of gamma irradiation on the biocompatibility and biodegradation of silk fibroin in vivo. Advanced Materials Research. 2012,535-537:2361-2364(EI).

15. Huanyu JinHua YinYu LiuYan An. The effect of gamma ray on the mechanical and molecular structure changes of silk fibroin. Advanced Material Research. 2012,502: 269-272(EI).

14. Dapeng Wang, Sanxiang Wang, Zhenghui Wang, Liming Zhang, Jian Li, Jian Liu,   Xing Liu, Huanyu Jin, Chunling Fu, Yan An. The arsenic concentration in saliva, urine and drinking water in endemic arsenicosis area in Shanyin county of Shanxi province, China. Applied Mechanics and Materials. 2012,140:465-468 (EI).

13. Dapeng Wang, Liming Zhang, Jian Li, Jian Liu, Xing Liu, Huanyu Jin, Chunyan Ji, Chunling Fu, Yan An. Comparison of the total arsenic between urine and saliva after consumption of seafood among volunteers.Conference on Environmental Pollution and Public Health. 2011, 271-273 (ISTP).

12. Chunyan Ji, Chunling Fu, Quanyong Xiang, Song Xu, Mingqing Zhu, Jian Liu, Dapeng Wang, Jie Zhang, Yan An. Biomarkers of early vascular endothelial injury with low-arsenic exposure in drinking water of Jiangsu province. Conference on Environmental Pollution and Public Health2011, 364-366. (ISTP).

11. Huanyu Jin, Hua Yin, Yan An. The application of radiation technology in the field of medical biomaterials. Advanced Material Research. 2011,287-290:1929-1932(EI).

10. Jian Liu, Sanxiang Wang, Zhenghui Wang, Dapeng Wang, Zhen Li, Xiaoping Wang, Xing Liu, Huanyu Jin, Yan An. The Relationship between Arseninc Exposure and Skin Lesions in Endemic Arsenicosis Area of Shanxi Province, China. 2011 International Conference on Human Health and Biomedical Engineering.2011,7:1198-1200 (EI).

9.  Dapeng Wang, Liming Zhang, Jian Li, Jian Liu, Xing Liu, Huanyu Jin, Chunyan Ji, Chunling Fu, Yan An. Disposition of arsenic in saliva, blood and urine of Sprague-Dawley rats following repeated oral exposure to sodium arsenite. 2011 International Conference on Human Health and Biomedical Engineering. 2011,61156-1159(EI).

8.  Jian Liu, Sanxiang Wang, Zhenghui Wang, Dapeng Wang, Zhen Li, Xiaoping Wang, Xing Liu, Huanyu Jin, Yoko Endo, Ginji Endo, Kenzo Yamanaka, Yan An. The level of aseninc in environmental media in endemic arsenism area of Shanxi province, China.Conference on Environmental Pollution and Public Health.2011, 301-304.(ISTP).

7.  Kenzo Yamanaka, Koichi Kato, Mutsumi Mizoi, Yan An, Masayuki Nakano, Mikio Hoshino, Shoji Okada. Dimethylarsine likely acts as a mouse-pulmonary tumor initiator via the production of dimethylarsine radical and/or its peroxy radical. Life Science. 2009, 84(17-18): 627-633.

DOI: 10.1016/j.lfs.2009.02.008

6.  Koichi Kato, Mutsumi Mizoi, Yan An, Masayuki Nakano, Hideki Wanibuchi, Ginji Endo, Mikio Hoshino, Shoji Okada, Kenzo Yamanaka. Oral administration of diphenylarsinic acid, a degradation product of chemical warfare agents, induces oxidative and nitrosative stress in cerebellar Purkinje cells. Life Science. 2007, 81(21-22): 1518-1525.

DOI: 10.1016/j.lfs.2007.09.030

5.  Mutsumi Mizoi, Fumiyo Takabayashi, Masayuki Nakano, Yan An, Yuko Sagesaka, Koichi Kato, Shoji Okada, Kenzo Yamanaka. The role of trivalent dimethylarsinic acid-promoted skin and lung tumorigenesis in Mice: Tumor promoting action through the induction of oxidative stress. Toxicology Letters.2005, 158(2): 87-94.

DOI:10.1016/j.toxlet.2005.03.009

4.  Yan An*, Koichi Kato , Masayuki Nakano, Hiroshi Otsu, Shoji Okada, Kenzo Yamanaka. Specific induction of oxidative stress in terminal bronchiolar Clara cells during dimethylarsenic-induced lung tumor promoting process in mice. Cancer Letters.2005, 230(1): 57-64.

DOI:10.1016/j.canlet.2004.12.029

3.  Yan An*, Zenglin Gao, Zhongwen Wang, Shaohe Yang, Jianfen Liang, Yan Feng, Koichi Kato, Masayuki Nakano, Shoji Okada, Kenzo Yamanaka. Immunohistochemical analysis of oxidative DNA damage in arsenic-related human skin samples from arsenic-contaminated area of China. Cancer Letters.2004, 214(1): 11-18.

DOI:10.1016/j.canlet.2004.04.005

2.  Kenzo Yamanaka, Koichi Kato , Mutsumi Mizoi , Yan An, Fumio Takabayashi, Masayuki Nakano, Mikio Hoshino, Shoji Okada. The role of active arsenic species produced by metabolic reduction of dimethylarsinic acid in genotoxicity and tumorigenesis. Toxicology and Applied Pharmacology. 2004,198: 385-393.

DOI:10.1016/j.taap.2003.10.025

1.  Kenzo Yamanaka, Fumio Takabayashi, Mutsumi Mizoi , Yan An, Akira Hasegawa, Shoji Okada. Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-Oxo-2’-deoxyguanosoine level, specifically in the target organs for arsenic carcinogenesis. Biochemical and Biophysical Research Communications.2001, 287 (1): 66-70.

DOI:10.1006/bbrc.2001.5551


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