张洁
姓名：张洁（1978.10-），女，江苏镇江人；职称：副教授硕士生导师（招生专业：卫生毒理学）。医学部公共卫生学院副院长。
1．学历
2006.09–2009.07 南京医科大学卫生毒理学专业 博士研究生
2004.09–2006.08 南京医科大学神经药理学专业 硕士研究生
1997.09–2002.07 江苏大学临床医学专业 大学本科
2．工作经历和任职情况
2014.09-至今 苏州大学医学部公共卫生学院卫生毒理学教研室 副教授
2009.08–2014.08 苏州大学医学部公共卫生学院卫生毒理学教研室 讲师
2013.2-2013.12 国家自然科学基金委 兼聘
2012.03–2012.04 美国哥伦比亚大学放射医学研究中心交流学习
2002.08–2004.08 江苏大学医学院药理教研室 助教
3．研究方向
环境毒理学，时间毒理学，生殖发育毒理学
主要从事环境内分泌干扰物对机体生物钟以及生殖发育的影响
4．承担课题情况
1) 国家自然科学基金面上项目，81673203、钟基因在双酚A所致斑马鱼发育毒性中的作用及机制研究、2016/01-2020/12、75万元、在研、主持。
2) 国家自然科学基金面上项目，81473008、氰戊菊酯对睾酮的昼夜毒性中钟基因Bmal1的作用及调控机制、2014/01-2018/12、85万元、在研、主持。
3) 江苏省高校自然科学基金面上项目，16KJB330009、节律基因在双酚A胚胎期暴露所致斑马鱼发育毒性中的作用、2016/09-2018/08、3万元、在研、主持。
4) 国家自然科学基金青年科学基金项目，81001257、氰戊菊酯对雄性生殖功能的昼夜时间毒性及其机制研究、2010/01-2014/12、19万元、结题、主持。
5) 苏州市科技计划项目，SYS201320、CLOCK基因多态性与男性不育的相关性及机制研究、2013/07-2016/06、4万元、结题、主持。
5．代表论文（(#第一作者, *通讯作者)
1) Wang D, Shimoda Y, Wang S, Wang Z, Liu J, Liu X, Jin H, Gao F, Tong J, Yamanaka K, Zhang J*, An Y*. Total Arsenic and Speciation Analysis of Saliva and Urine Samples from Individuals Living in Chronic Arsenicosis Area in China. Environ Health Prev Med. 2017 May 11;22(1):45. doi: 10.1186/s12199-017-0652-5.
2) Guo Y, Shen O, Han J, Duan H, Yang S, Zhu Z, Tong J, Zhang J*. Circadian rhythm genes mediate fenvalerate-induced inhibition of testosterone synthesis in mouse Leydig cells. J Toxicol Environ Health A. 2017;80(23-24):1314-1320. doi: 10.1080/15287394.2017.138-148. Epub 2017 Oct 17.
3) Han J, Ji C, Guo Y, Yan R, Hong T, Dou Y, An Y, Tao S, Qin F, Nie J, Ji C, Wang H, Tong J, Xiao W*, Zhang J*. Mechanisms underlying melatonin-mediated prevention of fenvalerate-induced behavioral and oxidative toxicity in zebrafish. J Toxicol Environ Health A.2017;80(23-24):1331-1341. doi: 10.1080/15287394.2017.1384167. Epub 2017 Nov 16.
4) Shen O(#),Ding X(#),Nie J,Xia Y,Wang X,Tong J,Zhang J*,Variants of the CLOCK gene affect the risk of idiopathic male infertility in the Han-Chinese population,Chronobiology International,2015,32(7):959-965。
5) Qin F(#),Zhang J(#),Zan L,Guo W,Wang J,Chen L,Cao Y,Shen O, Tong J*,Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors,Reproductive BioMedicine Online,2015,31(5):638-646。
6) Qin F (#), Zhang J(#),Cao H,Guo W,Chen L,Shen O,Sun J,Yi C,Li J,Wang J,Tong J*,Circadian alterations of reproductive functional markers in male rats exposed to 1800 MHz radiofrequency field, Chronobiology International,2014,31(1):123-133。
7) Zhang J(#),Ding X(#),Li Y,Xia Y,Nie J,Yi C,Wang X,Tong J *, Association of CLOCK gene variants with semen quality in idiopathic infertile Han-Chinese males,Reproductive BioMedicine Online,2012,25 (5):536-542。
8) Zhang J(#),Ding XL(#),Bian ZH,Xia YK,Wang SL,Song L,Wang XR*, Preparation and immunogenicity of tag-free recombinant human eppin,Asian Journalof Andrology,2011,13(6):889-894。
9) Zhang J(#) ,Ding X,Bian Z,Xia Y,Lu C,Wang S,Song L,Wang XR*, The effect of anti-eppin antibodies on ionophore A23187-induced calcium influx and acrosome reaction of human spermatozoa,Human Reproduction, 2010,25(1):29-36。
10) Ding X(#), Zhang J(#),Fei J,Bian Z,Li Y,Xia Y,Lu C,Song L,Wang S,Wang X*,Variants of the EPPIN gene affect the risk of idiopathic male infertility in the Han-Chinese population,Human Reproduction,2010, 25(7):1657-1665。
11) Ding X(#),Zhang J(#),Bian Z,Xia Y,Lu C,Gu A,Li Y,Song L,Wang S,Wang XR*,Variants in the Eppin gene show association with semen quality in Han-Chinese population,Reproductive BioMedicine Online,2010, 20(1):123-131。
6. 获奖情况：
1) 苏州市科学技术进步奖三等奖（2015）
2) 江苏省预防医学科技进步奖三等奖（2015）
7．联系方式
联系电话：0512-65880073 邮箱：zhangjie_78@suda.edu.cn
CURRICULUM VITAE
[GENERAL INFORMATION]
Name：Zhang Jie
Phone：86-051265880073 Email：zhangjie_78@suda.edu.cn
Research Direction: Environmental toxicology, .Reproductive and Developmental toxicology, Chronotoxicology
[EDUCATION]
2006-2009 Doctor (Medicine, Toxicology)
Nanjing Medical University, Nanjing, P.R.China
2004-2006 Master (Medicine, Pharmacology)
Nanjing Medical University, Nanjing, P.R.China
1997-2002 Bachelor (Clinical Medicine)
Jiangsu University, Zhenjiang, P.R.China
[WORKING EXPERIENCE]
2014.09 – Present, Department of toxicology, School of Public Health, Soochow University. Associate Professor
2009.08–2014.08, Department of toxicology, School of Public Health, Soochow University. Lecturer
2012.03–2012.04, Center for Radiological Research, Columbia University, Visiting Scholar
[GRANTS]
1)The National Nature Science Foundation of China (81673203): Mechanism of circadian clocks in Bisphenol A induced developmental toxicity of zebrafish. 2016/01-2020/12, PI
2)The National Nature Science Foundation of China (81473008): The effect of Bmal1 on the circadian chronotoxicity of testosterone in male mice exposure to fenvalerate. 2014/01-2018/12, PI
3)The University Science Research Project of Jiangsu Province (16KJB330009), Role of circadian genes in Bisphenol A induced developmental toxicity of zebrafish. 2016/09-2018/08, PI
4)The National Nature Science Foundation of China (8100125): The study on the circadian chronotoxicity of fenvalerate on male reproduction functions and its mechanisms. 2010/01-2014/12, PI
[PUBLICATIONS] ((#Co-1st authors, *Corresponding authors))
1) Wang D, Shimoda Y, Wang S, Wang Z, Liu J, Liu X, Jin H, Gao F, Tong J, Yamanaka K, Zhang J*, An Y*. Total Arsenic and Speciation Analysis of Saliva and Urine Samples from Individuals Living in Chronic Arsenicosis Area in China. Environ Health Prev Med. 2017 May 11;22(1):45. doi: 10.1186/s12199-017-0652-5.
2) Guo Y, Shen O, Han J, Duan H, Yang S, Zhu Z, Tong J, Zhang J*. Circadian rhythm genes mediate fenvalerate-induced inhibition of testosterone synthesis in mouse Leydig cells. J Toxicol Environ Health A. 2017;80(23-24):1314-1320. doi: 10.1080/15287394.2017.138-148. Epub 2017 Oct 17.
3) Han J, Ji C, Guo Y, Yan R, Hong T, Dou Y, An Y, Tao S, Qin F, Nie J, Ji C, Wang H, Tong J, Xiao W*, Zhang J*. Mechanisms underlying melatonin-mediated prevention of fenvalerate-induced behavioral and oxidative toxicity in zebrafish. J Toxicol Environ Health A.2017;80(23-24):1331-1341. doi: 10.1080/15287394.2017.1384167. Epub 2017 Nov 16.
4) Shen O(#),Ding X(#),Nie J,Xia Y,Wang X,Tong J,Zhang J*,Variants of the CLOCK gene affect the risk of idiopathic male infertility in the Han-Chinese population,Chronobiology International,2015,32(7):959-965。
5) Qin F(#),Zhang J(#),Zan L,Guo W,Wang J,Chen L,Cao Y,Shen O, Tong J*,Inhibitory effect of melatonin on testosterone synthesis is mediated via GATA-4/SF-1 transcription factors,Reproductive BioMedicine Online,2015,31(5):638-646。
6) Qin F (#), Zhang J(#),Cao H,Guo W,Chen L,Shen O,Sun J,Yi C,Li J,Wang J,Tong J*,Circadian alterations of reproductive functional markers in male rats exposed to 1800 MHz radiofrequency field, Chronobiology International,2014,31(1):123-133。
7) Zhang J(#),Ding X(#),Li Y,Xia Y,Nie J,Yi C,Wang X,Tong J *, Association of CLOCK gene variants with semen quality in idiopathic infertile Han-Chinese males,Reproductive BioMedicine Online,2012,25 (5):536-542。
8) Zhang J(#),Ding XL(#),Bian ZH,Xia YK,Wang SL,Song L,Wang XR*, Preparation and immunogenicity of tag-free recombinant human eppin,Asian Journalof Andrology,2011,13(6):889-894。
9) Zhang J(#) ,Ding X,Bian Z,Xia Y,Lu C,Wang S,Song L,Wang XR*, The effect of anti-eppin antibodies on ionophore A23187-induced calcium influx and acrosome reaction of human spermatozoa,Human Reproduction, 2010,25(1):29-36。
10) Ding X(#), Zhang J(#),Fei J,Bian Z,Li Y,Xia Y,Lu C,Song L,Wang S,Wang X*,Variants of the EPPIN gene affect the risk of idiopathic male infertility in the Han-Chinese population,Human Reproduction,2010, 25(7):1657-1665。
11) Ding X(#),Zhang J(#),Bian Z,Xia Y,Lu C,Gu A,Li Y,Song L,Wang S,Wang XR*,Variants in the Eppin gene show association with semen quality in Han-Chinese population,Reproductive BioMedicine Online,2010, 20(1):123-131。
[HONORS AND AWARDS]
1) The 3nd Grade of Science and Technology Advancement Award of Suzhou (2015)
2) The 3nd Grade of Science and Technology Advancement Award of Preventive Medicine of Jiangsu Province (2015)