薛莲

发布时间：2018-03-29 浏览次数：493

薛莲

姓名：薛莲（1976.09-），女，江苏江阴人；职称：副教授硕士生导师（招生专业：职业卫生与职业病）

1.学历

2006.09~2010.12	苏州大学放射生物学专业	PhD degree
2001.09~2004.07	苏州大学劳动卫生与环境卫生学专业	Master's degree
1994.09~1999.07	苏州大学(原苏州医学院)预防医学专业	Bachelor's degree

2.工作经历

2016.06~2016.09	日本国立放射线医学研究所，带电粒子治疗研究中心，日本学术振兴会(JSPS)邀请访问学者(JSPS Invitation Fellowship Program for Research in Japan)；
2015.06~2015.08	日本国立放射线医学研究所，次世代医学物理研究组，合作研究员；
2012.10~2013.10	日本国立放射线医学研究所，次世代医学物理研究组，公派访问学者；
2012.06~Present	苏州大学，公共卫生学院，劳动卫生与环境卫生学系，副教授；
2007.08~2008.06	日本国立放射线医学研究所，重离子放射生物学研究组，日本文部科学省奖学金研究员 (MEXT fellowship researcher)；
2005.05~2012.06	苏州大学，放射医学与公共卫生学院，劳动卫生与环境卫生学教研室，讲师；
1999.08~2005.05	原苏州医学院，放射医学与公共卫生系，助教。

3．研究方向

放射生物学

主要从事放射线生物学机制及肿瘤辐射增敏的研究。

4．承担课题情况

江苏省自然科学基金面上项目，BK20161219，ATR信号通路对肝细胞癌重离子治疗中辐射敏感性影响的研究，2016/07-2019/06，在研，主持；

国家自然科学基金青年科学基金项目，81102076，碳粒子束照射引起的人正常细胞低剂量超敏感现象及分子机制的研究，2012/01-2014/12，结题，主持。

5．代表论文 (^#第一作者, *通讯作者)

1). Xue Lian^#, Zhang Hong^#, Zhang Jie, Li Bingyan, Zhang Zengli*, Tao Shasha*. Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner. Toxicology Research. 2018. DOI: 10.1039/c7tx00304h.[Accepted]

2). Hirohiko Yajima^#*and Lian Xue. DNA repair processes and checkpoint pathways in human cells exposed to heavy ion beams. International Journal of Particle Therapy. 2016; 2(3):439-446.

3). Lian Xue^#, Yoshiya Furusawa, Dong Yu*. ATR pathway cooperates with ATM in the mechanism of low dose hypersensitivity induced by carbon ion beams. DNA repair, 2015 Oct;34:1-8..

4).Lian Xue^#, Yoshiya Furusawa, Ryuichi Okayasu, Masahiko Miura, Xing Cui, Cuihua Liu, Ryoichi Hirayama, Yoshitaka Matsumoto, Hirohiko Yajima*, Dong Yu*. The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function. DNA repair, 2015 Jan;25:72-83.

5). Lian Xue^#, Dong Yu, Yoshiya Furusawa, Jianping Cao, Ryuichi Okayasu, Saijun Fan. ATM dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions.Int. J. Radiation Oncology Biol. Phys., 2009 Sep 1;75(1):235-43.

6). Lian Xue^#*, Dong Yu*, Yoshiya Furusawa, Jian Tong, Jianping Cao, Ryuichi Okayasu, Saijun Fan. Regulation of ATM on DNA double strand breaks repair accounts for the radiosensitivity in high linear energy transfer ionizing radiation. Mutat Res-Fund Mol M., 2009 Nov 2;670(1-2):15-23. (Co-corresponding author)

7). Dong Yu^#, Emiko Sekine, Lian Xue, Akira Fujimori, Nobuo Kubota and Ryuichi Okayasu*. Sulphoraphane enhances radiosensitivity through inhibited DNA strand breaks repair pathways In hman tumor cells. Int. J of Cancer. 2009, 125(5):1205-11.

8). Zhou Jianhua^#*, Xue Lian, Zheng Shuanglai, et al. DNA lesion and HPRT mutant frequency in rat lymphocytes and V79 Chinese hamster lung cells exposed to cadmium, J Occup Health, 2006;48:93-99.

6. 获奖情况

1). 2006年度参与获得苏州市科技进步二等奖一项 (名列第二)
    2). 2009年度参与获得苏州市科技进步一等奖一项 (名列第四)
  3). 硕士论文获苏州大学优秀论文奖
    4). 2008年度获苏州大学青年教师课堂竞赛三等奖

7. 联系方式

联系电话：0512-65880074 E-mail：xuelian@suda.edu.cn

[GENERAL INFORMATION]

Name：Xue Lian

Phone：86-051265880074 Email：xuelian@suda.edu.cn

Research Direction: Radiobiology

[EDUCATIONAL DETAILS]

Date earned or expected	Name of University	Field of Study	Diploma/Degree
2006.09~2010.12	College of radiology and public health, Soochow University	Radiobiology	PhD degree
2001.09~2004.07	College of radiology and public health, Soochow University	Occupational and Environmental Health	Master's degree
1994.09~1999.07	The former Suzhou Medical College (having been merged into Soochow University)	Preventive Medicine	Bachelor's degree

[WORKING EXPERIENCE]

2016.06~2016.09	Invitation Fellowships of “JSPS Fellowship Programs for Overseas Researchers ” in QST-NIRS to study the biological effects of heavy ions
2015.06~2015.08	Collaborative research with NIRS for the beam times of heavy ion beams to study the biological effects of heavy ions
2012.10~2013.10	Government-sponsored overseas study for the collaborative research in NIRS to study the biological effects of heavy ions
2012.06~Present	Associate professor in School of Public Health, Medical College of Soochow University, China
2007.08~2008.06	MEXT fellowship researcher in National Institute of Radiological Sciences(NIRS) to study the biological effects of heavy ions
2005.05~2012.06	Lecturer in School of Public Health, Medical College of Soochow University, China
1999.08~2005.05	Assistant in School of Radiation Medicine and Public Health, Soochow University, China

[GRANTS]

1. The Nature Science Foundation of Jiangsu Province (BK20161219), The radiosensitizing effects of ATR pathway on hepatoma carcinoma cell with heavy particle treatment, 2016/07-2019/06, PI;

2. The National Nature Science Foundation of China (81102076), Study on the low-dose hyper-radiosensitivity (HRS) in normal human skin fibroblast cells exposed to carbon ion beams and the corresponding mechanism, 2012/01-2014/12, PI.

[MAIN PUBLICATIONS](^#Co-1st authors, *Corresponding authors)

1. Xue Lian^#, Zhang Hong^#, Zhang Jie, Li Bingyan, Zhang Zengli*, Tao Shasha*. Bixin protects against particle-induced long-term lung injury in an NRF2-dependent manner. Toxicology Research. 2018. DOI: 10.1039/c7tx00304h.[Accepted]

2. Hirohiko Yajima^#*and Lian Xue. DNA repair processes and checkpoint pathways in human cells exposed to heavy ion beams. International Journal of Particle Therapy. 2016; 2(3):439-446.

3. Lian Xue^#, Yoshiya Furusawa, Dong Yu*. ATR pathway cooperates with ATM in the mechanism of low dose hypersensitivity induced by carbon ion beams. DNA repair, 2015 Oct;34:1-8..

4.Lian Xue^#, Yoshiya Furusawa, Ryuichi Okayasu, Masahiko Miura, Xing Cui, Cuihua Liu, Ryoichi Hirayama, Yoshitaka Matsumoto, Hirohiko Yajima*, Dong Yu*. The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function. DNA repair, 2015 Jan;25:72-83.

5. Lian Xue^#, Dong Yu, Yoshiya Furusawa, Jianping Cao, Ryuichi Okayasu, Saijun Fan. ATM dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions.Int. J. Radiation Oncology Biol. Phys., 2009 Sep 1;75(1):235-43.

6. Lian Xue^#*, Dong Yu*, Yoshiya Furusawa, Jian Tong, Jianping Cao, Ryuichi Okayasu, Saijun Fan. Regulation of ATM on DNA double strand breaks repair accounts for the radiosensitivity in high linear energy transfer ionizing radiation. Mutat Res-Fund Mol M., 2009 Nov 2;670(1-2):15-23. (Co-corresponding author)

7. Dong Yu^#, Emiko Sekine, Lian Xue, Akira Fujimori, Nobuo Kubota and Ryuichi Okayasu*. Sulphoraphane enhances radiosensitivity through inhibited DNA strand breaks repair pathways In hman tumor cells. Int. J of Cancer. 2009, 125(5):1205-11.

8. Zhou Jianhua^#*, Xue Lian, Zheng Shuanglai, et al. DNA lesion and HPRT mutant frequency in rat lymphocytes and V79 Chinese hamster lung cells exposed to cadmium, J Occup Health, 2006;48:93-99.

[HONORS AND AWARDS]

1. The 1^st Grade of Science and Technology Advancement Award of Suzhou (2009) (Rank fourth);

2. The 2^nd Grade of Science and Technology Advancement Award of Suzhou (2006) (Rank second).