雷署丰(主任)

发布时间:2016-04-21  浏览次数:669

 

姓名:雷署丰,男,1975.10出生; 职称:特聘教授,博士生导师(招生专业:流行病与卫生统计学)

  

1、学历

2000.09-2003.06 湖南师范大学,生物化学与分子生物学硕士

2003.09-2005.01 湖南师范大学,生物化学与分子生物学博士

  

2、工作经历

2014--现在

江苏省老年病预防与转化医学重点实验室副主任

2012/02-现在

苏州大学医学部公共卫生学院,遗传流行病学与基因组学中心主任

2012/02-现在

苏州大学医学部公共卫生学院,特聘教授、博导

2010/01-2012/02

湖南师范大学生命科学学院,副研究员

2009/12-2011/01

美国密苏里大学,生物化学与分子生物学、兼职助理教授(研究)

2007/11-2009/12

美国密苏里大学,生物化学与分子生物学博士后

2003/07-2007/10

湖南师范大学生命科学学院,长江学者研究助手,中级、副研究员

3、研究方向

疾病生物标志物的鉴定与应用

4、科研成果

以骨质疏松症和类风湿性关节炎为主要研究对象,以阐明复杂疾病的遗传致病机理与环境风险因素,发现疾病相关生物标志物,开发预防、诊断、治疗复杂疾病的新型有效技术和手段为主要研究目标。从事分子遗传、遗传流行病学、统计遗传学、基因组与功能基因学、生物信息学等交叉科学的综合研究。在Endocr Rev、 Am J Hum Genet、Hum Mol Genet、J Bone Miner Res等杂志发表论文90余篇,其中第一、并列第一、通讯作者的SCI收录论文40余篇,SCI一区论文14 篇,SCI二区论文20篇,论文被引用总计达1000余次(SCI数据库),个人影响指数17(有17篇论文之上被引用17次以上)。

(1). 科研论文(选自84篇论文,#Co-1st authors, *Corresponding authors)

1.Lei SF, Deng FY, Liu XH, Huang QR, Qin Y, Zhou Q, Jiang DK, Li YM, Mo XY, Liu MY, Chen XD, Wu XS, Shen H, Dvornyk V, Zhao L, Recker RR, Deng HW. Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity. J Bone Miner Metab. 2003 21(1):34-42.

2.Lei SF, Deng FY, Li MX, Dvornyk V, Deng HW. Bone mineral density in elderly Chinese: effects of age, sex, weight, height, and body mass index. J Bone Miner Metab. 2004 22(1):71-78.

3.Lei SF#, Deng FY#, Dvornyk V, Liu MY, Xiao SM, Jiang DK, Deng HW. The (GT)n polymorphism and haplotype of the COL1A2 gene, but not the (AAAG)n polymorphism of the PTHR1 gene, are associated with bone mineral density in Chinese. Hum Genet. 2005; 116(3):200-207.

4.Lei SF, Deng FY, Xiao SM, Chen XD, Deng HW. Association and haplotype analyses of the COL1A2 and ER-a gene polymorphisms with bone size and height in Chinese. Bone 2005; 36:533– 541.

5.Lei SF, Zhang YY, Deng FY, Liu MY, Liu XH, Zhou XG, Deng HW. Bone mineral density and five prominent candidate genes in Chinese men: associations: Interaction effects and their implications. Maturitas. 2005 Jun 16; 51(2):199–206.

6.Zhang YY#, Lei SF#, Mo XY#, Wang YB, Li MX, Deng HW. The –1997 G/T Polymorphism in the COL1A1 upstream regulatory region is associated with hip bone mineral density in Chinese nuclear families. Calcif Tissue Int. 2005; 76:107–112.

7.Lei SF, Liu YZ, Deng FY, Li YM, Li MX, Deng HW. Association and linkage analyses of the interleukin-6 gene’s –634C/G polymorphism and bone phenotypes in Chinese. J Bone Miner Metab 2005; 23(4):323-328.

8.Lei SF, Wang YB, Liu MY, Mo XY, Deng HW. The VDR, COL1A1, PTH and PTHR1 Gene polymorphisms are not associated with bone size and height in Chinese nuclear families. Journal of Bone Mineral Metabolism. 2005;23(6):501-505.

9.Lei SF*, Wu S, Dvornyk V, Deng HW. Two strategies to identify genes underlying complex diseases. Current Genomics 2005; 6(7):551-561.

10.Lei SF, Liu MY, Chen XD, Deng FY, Lv JH, Jian WX, Xu H, Tan LJ, Yang YJ, Wang YB, Xiao SM, Sun X, Jiang C, Guo YF, Guo JJ, Li YN, Liu YJ and Deng HW. Relationship of total body fatness and five anthropometric indices in Chinese aged 20-40 y: Different effects of age and gender. Eur J Clin Nutr. 2006 Apr;60(4):511-8.

11.Sun X#, Lei SF#, Deng FY, Wu S, Papacian C, Hamilton J, Recker RR and Deng HW. Genetic and Environmental Correlations between Bone Geometric Parameters and Body Compositions in Caucasians. Calcif Tissue Int. 2006; 79(1):43-49.

12.Xiao SM#, Lei SF#, Chen XD, Liu MY, Jian WX, Xu H, Tan LJ, Deng FY, Yang YJ, Wang YB, XiaoS, Jiang C, Guo YF, Guo JJ, Li YN, and Deng HW. Correlation and prediction of trunk fat mass with four anthropometric indices in Chinese males. British Journal of Nutrition. 2006; 96:949–955.

13.Wang YB#, Lei SF#, Dvornyk V, Sun X, Jiang DK, Li MX, Deng HW. The Genetic, Environmental and Phenotypic Correlations of Bone Phenotypes at the Spine and Hip in Chinese. Ann Hum Biol. 2006; 33(4):500-9.

14.Yang F#, Lv JH#, Lei SF#, Chen XD, Liu MY, Jian WX, Xu H, Tan LJ, Deng FY, Yang YJ, Wang YB, Sun X, Xiao SM, Jiang C, Guo YF, Guo JJ, Li YN, Zhu XZ, Papasian CJ, Drees B and Deng HW. Receiver operating characteristic analysis of body mass index, waist circumference and waist-to-hip ratio for obesity: Screening in Chinese adult males and females. Clinical Nutrition 2006; 25(6): 1030-1039.

15.Jiang H#, Lei SF#, Xiao SM, Chen Y, Sun X, Yang F, Li LM, Wu S, Deng HW. Association and linkage analysis of the COLlA1 and AHSG gene polymorphisms with femoral neck bone geometric parameters in both Caucasian and Chinese nuclear families. Acta Pharmacol Sin. 2007 Mar;28(3):375-81.

16.Lei SF, Chen Y, Li LM, Xiong DH, Deng HW. Ethnic difference in osteoporosis-related phenotypes and its potential underlying genetic determination. J Musculoskelet Neuronal Interact. 2006; 6(1):36-46.

17.Xiong DH#, Lei SF#, Yang F, Wang L, Peng YM, Wang W, Recker RR, Deng HW. Low-density Lipoprotein Receptor-Related Protein 5 (LRP5) Gene Polymorphisms Were Associated with Bone Mass in Both Chinese and Caucasians. J Bone Miner Res. 2007 Mar;22(3):385-93.

18.Wu S#, Lei SF#, Chen XD, Tan LJ, Jian WX, Deng FY, Sun X, Xiao SM, Jiang C, Guo YF, Zhu XZ, Deng HW. The contributions of lean tissue mass and fat mass to bone geometric adaptation at the femoral neck in Chinese overweight adults. Ann Hum Biol. 2007 May-Jun;34(3):344-53.

19.Lei SF, Jiang H, Deng HW. Searching for genes underlying susceptibility to osteoporotic fracture: Current progress and future prospects. Osteoporos Int 2007; 18:1157–1175.

20.Jiang C#, Lei SF#, Liu MY, Xiao SM, Chen XD, Deng FY, Xu H, Tan LJ, Yang YJ, Wang YB, Sun X, Guo YF, Guo JJ and Deng HW. Evaluating the correlation and prediction of trunk fat mass with five anthropometric indices in Chinese females aged 20-40 years. Nutrition, Metabolism&Cardiovascular Diseases.2007;17(9):676-83.  

21.Li LM#, Lei SF#, Chen XD, Tan LJ, Deng FY, Zhu XZ, Deng HW. Anthropometric indices as the predictors of trunk obesity in Chinese young adults: Evaluation using receiver operating characteristic curves. Ann Hum Biol 2008; 35(3):342-348.

22.Lei SF, Yang TL, Tan LJ, Chen XD, Guo Y, Zhang L, Liu XG, Yan H, Pan F, Zhang ZX,  Peng YM, Zhou Q, He LN, Zhu XZ, Deng FY, Cheng J, Liu YZ, Papasian CJ and Deng HW. Genome-wide association scan for stature in Chinese: Evidence for ethnic specific loci. Human Genetics 2009 Feb;125(1):1-9.

23.Lei SF, Deng FY, Xiao P, Deng HY, Recker RR, Deng HW. Bivariate whole-genome linkage scan for total body fat mass and bone geometry. Journal Genetics and Genomics 2009; 36(2):89-97.

24.Lei SF, Wu S, Li LM, Deng FY, Xiao SM, Jiang C, Chen Y, Jiang H, Yang F, Tan LJ, Sun X, Zhu XZ, Liu MY, Liu YZ, Chen XD, and Deng HW. An in Vivo Genome Wide Gene Expression Study of Circulating Monocytes suggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass. Bone 2009 May; 44:1010-1014.

25.Lei SF, Tan LJ, Liu XG, Wang L, Yan H, Guo YF, Liu YZ, Xiong DH, Li J, Yang TL, Chen XD, Guo Y, Deng FY, Zhang YP, Zhu XZ, Levy S, Papasian CJ, Hamilton JJ, Recker RR, Deng HW. Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation. Hum Mol Genet. 2009 May 1;18(9):1661-9. Epub 2008 Nov 27.

26.Lei SF, Papasian CJ, Deng HW. Polymorphisms in predicted miRNA binding sites and osteoporosis. J Bone Miner Res. 2011 Jan;26(1):72-8.

27.Liu SL, Lei SF*, Yang F, Li X, Liu R, Nie S, Liu XG, Yang TL, Guo Y, Deng FY, Tian Q, Li J, Liu YZ, Liu YZ, Shen H, Deng HW*. Copy number variation in CNP267 region may be associated with hip bone size. PLoS ONE 2011;6(7):e22035.

28.Deng FY, Lei SF* Chen XD, Tan LJ, Zhu XZ and Deng HW*. An Integrative Study Ascertained SOD2 as a Susceptibility Gene for Osteoporosis in Chinese. J Bone Miner Res. 2011 Nov;26(11):2695-701.

29.Lei SF*, Shen H, Yang TL, Guo Y, Dong SS, Xu XH, Deng FY, Tian Q, Liu YJ, Liu YZ, Li J, Deng HW*. Genome-Wide Association Study Identifies HMGN3 Locus for Spine Bone Size Variation in Chinese. Human Genetics. 2012 131:463–469.

30.Zhong K#, Lei SF#, Yang F, Chen XD, Tan LJ, Zhu XZ, Tian Q and Deng HW. The differences of sarcopenia related phenotypes:Effects of gender and population. European Review of Aging and Physical Activity. 2012; 9(1)-63-69.

31.Deng FY, Lei SF*, Zhang YH, Zhang ZL, Guo YF. Functional relevance for associations between genetic variants and systemic lupus erythematosus. 2013 PLoS One. e53037.

32.Deng FY, Lei SF*, Zhang YH, Zhang ZL. Integrative analyses for detection of functional mechanisms underlying associations for rheumatoid arthritis. 2013. Journal of Rheumatology. 2013 Jul;40(7):1063-8.

33.Zhu H, Deng FY, Mo XB, Qiu YH, Lei SF*. Pharmacogenetics and pharmacogenomics for rheumatoid arthritis responsiveness to methotrexate treatment: The 2013 update. Pharmacogenomics. 2014 Mar; 15(4):551-566.

34.Lei SF, Deng FY. Identification of susceptibility genes for systemic lupus erythematosus with a genome-wide gene-based association study.  Scandinavian Journal of Rheumatology. 2014;43(5):426-7.

35.Qiu YH, Deng FY, Li MJ, Lei SF*. Identification of Novel Risk Genes Associated with Type 1 Diabetes Mellitus Using a Genome-wide Gene-Based Association Analysis. Journal of Diabetes Investigation, 2014; 5: 649–656.

36.Zhu XW, Deng FY, Lei SF*. Meta-Analysis of Atherogenic Index of Plasma and Other Lipid Parameters in Relation to Risk of Type 2 Diabetes Mellitus. Primary Diabetes Care. 2015; 9:60-67.

37.Lin X, Deng FY, Mo XB, Wu LF, Lei SF*. Functional Relevance for Multiple Sclerosis-associated Genetic Variants. Immunogenetics 2015; 67:7-14.

38.Lin X, Deng FY, Lu X, Lei SF*. Gene-based genome-wide association study identified susceptibility genes for multiple sclerosis. J Clin Neurol. 2015 Oct;11(4):311-8.

39.Zhu XW, DengFY, Wu LF, Lu X, Lei SF*. Functional Mechanisms for Type 2 Diabetes-associated Genetic Variants. Journal of Diabetes and its Complications. 2015 May-Jun;29(4):497-501.

40.Mo XB, Lu X, Zhang YH, Zhang ZL, Deng FY, Lei SF*. Gene-Based Association Analysis Identified Novel GenesAssociated with Bone Mineral Density. PLoS One. 2015 Mar 26;10(3):e0121811

41.Qiu YH, Deng FY, Tang ZX, Jiang ZH*, Lei SF*. Functional relevance for type 1 diabetes mellitus-associated genetic variants by using integrative analyses.Hum Immunol. 2015 Sep 30

  

(2)获奖

1)邓红文、陈湘定、莫小阳、刘曼媛、雷署丰、刘湘华,2003 年度湖南省科学技术进步奖二等奖(2003-230-065)

2)邓红文、邓飞艳、张圆圆、谭远德、雷署丰,教育部提名国家科学技术奖自然科学奖二等奖 2004.12

3)雷署丰,国际骨质疏松高级研讨会 2003 IOC 优秀青年学者奖三等奖 2003.10

  

(3)出版物

1)邓红文,刘耀中,陈棣,郭春远,陈湘定,雷署丰(副主编),王勇军 2005 《骨生物学前沿》高等教育出版社。

2)邓红文,刘耀中,陈棣,郭春远,雷署丰(副主编),陈湘定 2006 《骨质疏松学前沿》高等教育出版社。

(4)承担和参加的科研项目情况

项目名称

来源

经费

(万元)

起止年月

角色

1

类风湿性关节炎相关miRNA的鉴定以及血浆miRNA标志物的筛选与评价研究

国家自然科学基金面上项目

80

2015.01-

2018.12

主持人

2

启动子区域遗传多态性位点与骨质疏松关联机制研究

国家自然科学基金面上项目

81

2013.01-

2016.12

主持人

3

苏州大学人才引进基金

苏州大学

400

2012.02-

2017.02

主持人

4

miRNA靶位点遗传多态性调控骨质疏松机理研究

国家自然科学基金面上项目

36

2011.01-

2013.12

主持人

5

中国和加拿大人群中肥胖基因的研究:重复性的证据与种族和性别差异的研究

国家自然科学基金国际合作计划

45

2009.01-

2011.12

主持人

6

高低尾峰值骨量组间破骨细胞前体的差异表达蛋白的验证与鉴定

国家自然科学基金面上项目

21

2007.01-

2009.12

主持人

7

四个中国I型成骨不全家系的致病基因突变位点鉴定

湖南省自然科学基金

3

2005.1-

2006.12

主持人

8

三种常见疾病和其它环境因素对青壮年高峰骨质和骨代谢的影响

教育厅优秀青年项目

3.5

2005.1-

2006.12

主持人

5. 联系方式

联系电话:0512-65883357, E-mail:leisf@suda.edu.cn

 

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