个人简介
雷署丰，博士，苏州大学特聘教授，博士生导师。现为苏州大学苏州医学院公共卫生学院院长助理，重大慢性病预防与转化医学省高校重点实验室副主任，遗传流行病学与基因组学研究中心主任。
【教育经历】
2000.09-2003.06 湖南师范大学，生物化学与分子生物学，硕士
2003.09-2005.01 湖南师范大学，生物化学与分子生物学，博士
【工作经历】
2012/02-现在 | 苏州大学医学部公共卫生学院，特聘教授、博导 |
2014--现在 | 江苏省老年病预防与转化医学重点实验室副主任 |
2012/02-现在 | 遗传流行病学与基因组学中心主任 |
2007/11-2012/02 | 湖南师范大学生命科学学院，副研究员 |
2009/12-2011/01 | 美国密苏里大学，兼职助理教授（研究） |
2007/11- 2009/12 | 美国密苏里大学，生物化学与分子生物学博士后 |
2003/07-2007/10 | 湖南师范大学生命科学学院，长江学者研究助手 |
【讲授课程】
《分子流行病学》、《预防医学科研设计》、《常见病分子病因新进展》
【招生方向】
流行病与卫生统计学
【研究方向】
骨质疏松症和类风湿性关节炎的生物标志物的鉴定与应用研究。
骨质疏松症是一种全身性骨骼疾病，表现为骨密度和骨质量下降，骨微结构破坏，造成骨脆性增加，易发生低创伤性骨折。骨质疏松症严重影响我国老年人健康，中国50岁以上人群骨质疏松症总患病率为15.7%。骨质疏松症患者易发生骨质疏松症 骨折，常见的髋部骨质疏松症 骨折危害最大，预计2020年我国髋部骨质疏松症骨折患者将达到164万，30%的患者因长期卧床而引发各种并发症（如静脉栓塞、泌尿系统感染等）导致死亡。随着我国人口老龄化加剧，骨质疏松症发病率将逐年上升，问题将日益严重。因此，对骨质疏松症进行有效防治刻不容缓。
骨质疏松症被称为“静悄悄”的流行病，其病程长，在骨质疏松症骨折发生前，通常无特殊症状，极易被人忽视，目前人们还未充分认识到骨质疏松症的危害性。在世界范围内骨质疏松症致病机理解析研究还处于起步阶段，在国内很多研究方向还是空白。
目前课题组正在建设国内首个“骨质疏松症的预防与控制”大型前瞻性队列。该队列研究旨在建立稳定的随访群体，重点研发骨质疏松症的危险因素和预警生物标志物，构建风险预测模型，开发预防和干预的方法。该队列针对60岁以上社区老年群体，即骨质疏松症高发人群，全面收集了血常规、尿常规、生化全套、吸烟情况、饮酒情况、膳食习惯、家族史、月经史、疾病史、体力活动、平衡能力、跌倒风险评估、双能X线的骨密度（金标准）、人体成分等临床信息。自2014年始建至今，已完成2.2万例样本的基线调查和两次随访调查（2年一次），累计收集血浆、红细胞、尿液、粪便等生物学样本25万余份。
面对我国人口老龄化加剧骨质疏松症日益高发的严峻现实，针对骨质疏松症的复杂决定机制，基于正在建设的大型前瞻性“骨质疏松症预防与控制”队列，课题组将运用“二级预防”理念，聚焦骨质疏松症的早发现、早诊断、早治疗，筛选早期预警生物标志物，建立中国人群特异的风险预警模型，提出并采取行之有效的预防和治疗措施，以降低骨质疏松症发病率，实现骨质疏松症预防和控制的主要目标，最终提高老年人的健康水平，助力“健康中国”建设。
【科研成果】
在Ann Rheum Dis、J Bone Miner Res等杂志发表论文200余篇，其中第一与通讯作者的SCI收录论文100余篇。累计主持国家自然科学基金8项，获省部级二等奖3次。作为副主编在高等教育出版社出版两本骨学著作《骨生物学前沿》、《骨质疏松学前沿》。2021、2022年连续入选“全国老年医学领域专家国际论文学术影响力”百强排名榜。
【科研论文】#并列第一，*通讯作者
1.Lei SF, Deng FY, Liu XH, Huang QR, Qin Y, Zhou Q, Jiang DK, Li YM, Mo XY, Liu MY, Chen XD, Wu XS, Shen H, Dvornyk V, Zhao L, Recker RR, Deng HW. Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populationsofdifferentethnicity. J Bone Miner Metab. 2003 21(1):34-42. (IF: 1.553)
2.Lei SF, Deng FY, Li MX, Dvornyk V, Deng HW. Bone mineral density in elderly Chinese: effects of age, sex, weight, height, and body mass index. J Bone Miner Metab. 2004 22(1):71-78. (IF: 1.496)
3.Lei SF#, Deng FY#, Dvornyk V, Liu MY, Xiao SM, Jiang DK, Deng HW. The (GT)n polymorphism and haplotype of the COL1A2 gene, but not the (AAAG)n polymorphism of the PTHR1 gene, are associated with bone mineral density in Chinese. Hum Genet. 2005; 116(3):200-207. (IF: 4.331,II区)
4.Lei SF, Deng FY, Xiao SM, Chen XD, Deng HW. Association and haplotype analyses of the COL1A2 and ER- gene polymorphisms with bone size and height in Chinese. Bone 2005; 36:533– 541. (IF: 3.939,II区)
5.Lei SF, Zhang YY, Deng FY, Liu MY, Liu XH, Zhou XG, Deng HW. Bone mineral density and five prominent candidate genes in Chinese men: associations:interaction effects and their implications. Maturitas. 2005; 51(2):199–206.(IF: 2.004)
6.Zhang YY#, Lei SF#, Mo XY#, Wang YB, Li MX, Deng HW. The –1997 G/TPolymorphismin the COL1A1 upstream regulatory region is associated with hip bone mineral density in Chinese nuclear families. Calcif Tissue Int. 2005; 76:107–112. (IF: 2.487)
7.Lei SF, Liu YZ, Deng FY, Li YM, Li MX, Deng HW. Association and linkage analyses of the interleukin-6 gene’s –634C/G polymorphism and bone phenotypes in Chinese. J Bone Miner Metab 2005; 23(4):323-328. (IF: 1.464)
8.Lei SF, Wang YB, Liu MY, Mo XY, Deng HW. The VDR, COL1A1, PTH and PTHR1Genepolymorphisms are not associated with bone size and height in Chinese nuclear families. Journal of Bone Mineral Metabolism. 2005;23(6):501-505. (IF: 1.464)
9.Lei SF*, Wu S, Dvornyk V, Deng HW. Two strategies to identify genes underlying complex diseases. Current Genomics 2005; 6(7):551-561. (IF: 0.786)
10.Lei SF, Liu MY, Chen XD, Deng FY, Lv JH, Jian WX, Xu H, Tan LJ, Yang YJ, Wang YB, Xiao SM, Sun X, Jiang C, Guo YF, Guo JJ, Li YN, Liu YJ and Deng HW. Relationship of total body fatness and five anthropometric indices in Chinese aged 20-40y: Different effects of age and gender. Eur J Clin Nutr. 2006; 60(4):511-8. (IF：2.116)
11.Sun X#, Lei SF#, Deng FY, Wu S, Papacian C, Hamilton J, Recker RR and Deng HW. Genetic and Environmental Correlations between Bone Geometric Parameters and Body Compositions in Caucasians. Calcif Tissue Int. 2006; 79(1):43-49. (IF: 2.483)
12.Xiao SM#, Lei SF#, Chen XD, Liu MY, Jian WX, Xu H, Tan LJ, Deng FY, Yang YJ, Wang YB, XiaoS, Jiang C, Guo YF, Guo JJ, Li YN, and Deng HW. Correlation and prediction of trunk fat mass with four anthropometric indices in Chinese males. British Journal of Nutrition. 2006; 96:949–955.(IF: 2.708)
13.Wang YB#, Lei SF#, Dvornyk V, Sun X, Jiang DK, Li MX, Deng HW. The Genetic, Environmental and Phenotypic Correlations of Bone Phenotypes at the Spine and Hip in Chinese. Ann Hum Biol. 2006; 33(4):500-9. (IF: 0.778)
14.Yang F#, Lv JH#, Lei SF#, Chen XD, Liu MY, Jian WX, Xu H, Tan LJ, Deng FY, Yang YJ, Wang YB, Sun X, Xiao SM, Jiang C, Guo YF, Guo JJ, Li YN, Zhu XZ, Papasian CJ, Drees B and Deng HW. Receiver operating characteristic analysis of body mass index, waist circumference and waist-to-hip ratio for obesity: Screening in Chinese adult males and females. Clinical Nutrition. 2006; 25(6): 1030-1039. (IF: 2.474)
15.Jiang H#, Lei SF#, Xiao SM, Chen Y, Sun X, Yang F, Li LM, Wu S, Deng HW. Association and linkage analysis of the COLlA1 and AHSG gene polymorphisms with femoral neck bone geometric parameters in both Caucasian and Chinese nuclear families. Acta Pharmacol Sin. 2007; 28(3):375-81. (IF: 1.677)
16.Lei SF, Chen Y, Li LM, Xiong DH, Deng HW. Ethnicdifferenceinosteoporosis-related phenotypesanditspotentialunderlyinggeneticdetermination. J Musculoskelet Neuronal Interact. 2006; 6(1):36-46.
17.Xiong DH#, Lei SF#, Yang F, Wang L, Peng YM, Wang W, Recker RR, Deng HW. Low-densityLipoproteinReceptor-RelatedProtein5 (LRP5)GenePolymorphismsWereAssociatedwithBoneMassinBothChinese and Caucasians. J Bone Miner Res. 2007; 22(3):385-93. (IF: 6.004 , I 区)
18.Wu S#, Lei SF#, Chen XD, Tan LJ, Jian WX, Deng FY, Sun X, Xiao SM, Jiang C, Guo YF, Zhu XZ, Deng HW. The contributions of lean tissue mass and fat mass to bone geometric adaptation at the femoral neck in Chinese overweight adults. Ann Hum Biol. 2007; 34(3):344-53. (IF: 1.06)
19.Lei SF, Jiang H, Deng HW. Searching for genes underlying susceptibility to osteoporotic fracture: Current progress and future prospects.OsteoporosInt. 2007; 18:1157–1175. (IF: 3.893,II区)
20.Jiang C#, Lei SF#, Liu MY, Xiao SM, Chen XD, Deng FY, Xu H, Tan LJ, Yang YJ, Wang YB, Sun X, Guo YF, Guo JJ and Deng HW. Evaluating the correlation and prediction of trunk fat mass with five anthropometric indices in Chinese females aged 20-40 years.Nutr Metab Cardiovasc Dis. 2007; 17(9):676-83. (IF: 3.174)
21.Li LM#, Lei SF#, Chen XD, Tan LJ, Deng FY, Zhu XZ, Deng HW. Anthropometric indicesasthepredictorsof trunk obesity in Chinese young adults: Evaluation using receiver operating characteristic curves. Ann Hum Biol. 2008; 35(3):342-348.(IF: 1.009)
22.Lei SF, Yang TL, Tan LJ, Chen XD, Guo Y, Zhang L, Liu XG, Yan H, Pan F, Zhang ZX, Peng YM, Zhou Q, He LN, Zhu XZ, Deng FY, Cheng J, Liu YZ, Papasian CJ and Deng HW. Genome-wide association scan for stature in Chinese: Evidence for ethnic specific loci. Human Genetics. 2009; 125(1):1-9. (IF: 4.523,II区)
23.Lei SF, Deng FY, Xiao P, Deng HY, Recker RR, Deng HW. Bivariate whole-genome linkage scan for total body fat mass and bone geometry.JournalGenetics and Genomics. 2009; 36(2):89-97. (IF: 0.813)
24.Lei SF, Wu S, Li LM, Deng FY, Xiao SM, JiangC, Chen Y, Jiang H, Yang F, Tan LJ, Sun X, Zhu XZ, Liu MY, Liu YZ, Chen XD, and Deng HW. AninVivoGenomeWideGeneExpressionStudyofCirculatingMonocytessuggested GBP1, STAT1 and CXCL10 as novel risk genes for the differentiation of peak bone mass. Bone. 2009; 44:1010-1014. (IF: 4.089,II区)
25.Lei SF, Tan LJ, Liu XG, Wang L, Yan H, Guo YF, Liu YZ, Xiong DH, Li J, Yang TL, Chen XD, Guo Y, Deng FY, Zhang YP, Zhu XZ, Levy S, Papasian CJ, Hamilton JJ, Recker RR, Deng HW. Genome-wide association study identifies two novel loci containing FLNB and SBF2 genes underlying stature variation. Hum Mol Genet. 2009; 18(9):1661-9. (IF: 7.386 ,II区)
26.Lei SF, Papasian CJ, Deng HW. Polymorphisms in predicted miRNA binding sites and osteoporosis. J Bone Miner Res. 2011 Jan;26(1):72-8. (IF: 6.373 , I 区)
27.Liu SL, Lei SF*, Yang F, Li X, Liu R, Nie S, Liu XG, Yang TL, Guo Y, Deng FY, Tian Q, Li J, Liu YZ, Liu YZ, Shen H, Deng HW*. Copy number variationinCNP267 region may be associated with hip bone size. PLoSOne. 2011; 6(7):e22035.(IF: 4.092)
28.Deng FY, Lei SF# Chen XD, Tan LJ, Zhu XZ and Deng HW#.An Integrative Study Ascertained SOD2 as a Susceptibility Gene for Osteoporosis in Chinese. J Bone Miner Res. 2011; 26(11):2695-701. (IF: 6.373 , I 区)
29.Lei SF*, Shen H, Yang TL, Guo Y, Dong SS, Xu XH, Deng FY, Tian Q, Liu YJ, Liu YZ, Li J, Deng HW#. Genome-Wide Association Study Identifies HMGN3 Locus for Spine Bone Size Variation in Chinese. Human Genetics. 2012; 131:463–469. (IF: 4.633 ,II区)
30.Zhong K#, Lei SF#, Yang F, Chen XD, Tan LJ, Zhu XZ, Tian Q and Deng HW. The differences of sarcopenia related phenotypes: Effects of gender and population. European Review of Aging and Physical Activity. 2012; 9(1)-63-69. (IF: 0.909)
31.Deng FY, Lei SF*, Zhang YH, Zhang ZL, Guo YF. Functional relevance for associations between genetic variants and systemic lupus erythematosus. PLoSOne. 2013; 8(1):e53037. (IF: 3.534)
32.Deng FY, Lei SF*, Zhang YH, Zhang ZL. Integrative analysesfordetection of functional mechanisms underlying associations for rheumatoid arthritis. Journal of Rheumatology. 2013; 40(7):1063-8. (IF: 3.173)
33.Zhu H, Deng FY, Mo XB, Qiu YH, Lei SF*. Pharmacogenetics and pharmacogenomics for rheumatoid arthritis responsiveness to methotrexate treatment: The 2013 update. Pharmacogenomics. 2014; 15(4):551-566. (IF: 3.218)
34.Lei SF, Deng FY. Identification of susceptibility genes for systemic lupus erythematosus with a genome-wide gene-based association study. Scandinavian Journal of Rheumatology. 2014; 43(5):426-428. (IF: 2.527)
35.Qiu YH, Deng FY, Li MJ, Lei SF*. Identification of Novel Risk Genes Associated with Type 1 Diabetes Mellitus Using a Genome-wideGene-Based Association Analysis. Journal of Diabetes Investigation. 2014; 5: 649–656. (IF: 1.825)
36.Zhu XW, Deng FY, Lei SF*. Meta-Analysis of Atherogenic Index of Plasma and Other Lipid Parameters inRelationtoRiskof Type 2 Diabetes Mellitus. Primary Care Diabetes. 2015; 9:60-67. (IF: 1.325)
37.Lin X, Deng FY, Mo XB, Wu LF, Lei SF*. Functional Relevance for Multiple Sclerosis-associated Genetic Variants. Immunogenetics. 2015; 67:7-14.(IF: 2.303)
38.Lin X, Deng FY, Lu X, Lei SF*. Gene-based genome-wide association study identified susceptibility genes for multiple sclerosis. J Clin Neurol. 2015; 11(4):311-8. (IF: 1.876)
39.Zhu XW, DengFY, Wu LF, Lu X, Lei SF*. Functional Mechanisms for Type 2 Diabetes-associated Genetic Variants. Journal of Diabetes and its Complications. 2015; 29(4):497-501. (IF: 2.955)
40.Mo XB, Lu X, Zhang YH, Zhang ZL, Deng FY, Lei SF*. Gene-Based Association Analysis Identified Novel Genes Associated with Bone Mineral Density. PLoSOne. 2015; 10(3):e0121811. (IF: 3.057)
41.Qiu YH, Deng FY, Tang ZX, Jiang ZH*, Lei SF*.Functional relevance for type 1 diabetes mellitus-associated genetic variants by using integrative analyses. Hum Immunol. 2015; 76(10):753-8. (IF: 2.127)
42.Zhu H, Xia W, Mo XB, Lin X, Qiu YH, Yi NJ, Zhang YH, Deng FY, Lei SF*.Gene-Based Genome-Wide Association Analysis in European and Asian Populations Identified Novel Genes for Rheumatoid Arthritis. PLoSOne. 2016; 11(11):e0167212. (IF: 2.806)
43.Xia W#, Wu J#, Deng FY, Wu LF, Zhang YH, Guo YF*, Lei SF*.Integrative analysisforidentification of shared markers from various functional cells/tissues for rheumatoid arthritis. Immunogenetics. 2017; 69(2):77-86.(IF: 2.094)
44.Xia W, Zhu XW, Mo XB, Wu LF, Wu J, Guo YF, Zeng KQ, Wang MJ, Lin X, Qiu YH, Wang L, He P, Xie FF, Bing PF, Lu X, Liu YZ, Yi NJ, Deng FY, Lei SF*. Integrative multi-omics analysis revealed SNP-lncRNA-mRNA (SLM) networks in human peripheral blood mononuclear cells. Hum Genet. 2017; 136(4):451-462. (IF: 3.930 ,II区）
45.Mo XB, Wu LF, Zhu XW, Xia W, Wang L, He P, Bing PF, Lu X, Zhang YH, Deng FY, Lei SF*.Identification and evaluation of lncRNA and mRNA integrative modules in human peripheral blood mononuclear cells. Epigenomics. 2017; 9(7):943-954. (IF: 4.979 ,II区)
46.Lin X, Xia W, Ji W, Xie FF, He P, Zhu XW, Zhang YH, Deng FY*, Lei SF*. Genome-wide integrative analysis identified SNP-miRNA-mRNA interaction networks in peripheral blood mononuclear cells. Epigenomics. 2017; 9(10):1287-1298. (IF: 4.979 ,II区)
47.Xie FF, Deng FY, Wu LF, Mo XB, Zhu H, Wu J, Guo YF, Zeng KQ, Wang MJ, Zhu XW, Xia W, Wang L, He P, Bing PF, Lu X, Zhang YH, Lei SF*. Multiple correlation analysesrevealedcomplex relationship between DNA methylation and mRNA expression in human peripheral blood mononuclear cells. Functional & Integrative Genomics. 2018; 18(1):1-10.(IF: 2.745)
48.Wang L#, Zhu J#, Deng FY, Wu LF, Mo XB, Zhu XW, Xia W, Xie FF, He P, Bing PF, Qiu YH, Lin X, Lu X, Zhang L, Yi NJ, Zhang YH, Lei SF*. Correlation analyses revealed global microRNA-mRNA expression associations in human peripheral blood mononuclear cells. Mol Genet Genomics. 2018; 293:95–105.(IF: 2.879)
49.Lu YH, Wang BH, Xia W, Mo XB, Wu LF, Zhu XW, He P, Xie FF, Lu X, Deng FY*, Lei SF*. The distribution and functional relevance analysis of runs of homozygosity (ROHs)inChineseHan female population. Mol Genet Genomics. 2018; 293:197–206. (IF: 2.879)
50.Wu LF, Zhu DC, Wang BH, Lu YH, He P, Zhang YH, Gao HQ, Zhu XW, Xia W, Zhu H, Mo XB, Lu X, Zhang L, Zhang YH, Deng FY*, Lei SF*. Relative abundance of mature myostatin rather than total myostatin is negatively associated with bone mineral density in Chinese. J Cell Mol Med. 2018; 22(2):1329-1336. (IF: 4.658 ,II区)
51.Zhu XW#, Yu LG#, Zhou H, Ma QH , Zhou XH, Lei T, Hu JR, Xu WX, Yi NJ, Lei SF*. Atherogenic index of plasma is a novel and better biomarker associated with obesity: a population-based cross-sectional study in China. Lipids in Health and Disease. 2018; 17(1):37. (IF: 2.651)
52.Wang WY#, Ge B#, Shi J, Zhou X, Wu LF, Tang CH, Zhu DC, Zhu H, Mo XB, Zhang YH, Deng FY, Lei SF* Plasma gelsolin is associated with hip BMD in Chinese postmenopausal women PLoS One 2018; 13(5): e0197732.(IF: 2.776)
53.Wu LF#, Zhu DC#, Tang CH, Ge B, Shi J, Wang BH, Lu YH, He P, Wang WY, Lu SQ, Zhong J, Zhou X, Zhu K, Ji W, Gao HQ, Gu HB, Mo XB, Lu X, Zhang L, Zhang YH, Deng FY, Lei SF*. Association of Plasma Irisin with Bone Mineral Density in a Large Chinese Population Using an Extreme Sampling Design. Calcified Tissue International. 2018; 103:246–251. (IF: 3.265)
54.Mo XB, Zhang YH, Lei SF*. Genome-wide identification of m6A-associated SNPs as potential functional variants for bone mineral density. Osteoporosis International. 2018; 29:2029–2039. (IF: 3.830 ,II区)
55.Mo XB, Zhang YH, Lei SF*. Genome-wide identification of N6-methyladenosine (m6A) SNPs associated with rheumatoid arthritis. Frontiers in Genetics. 2018; 9:299. (IF: 3.517 ,II区)
56.Mo XB, Wu LF, Cai XM, Tang ZX, Lu X, Zhang YH, Deng FY, Lei SF*. Integrative analysis identified mediation effects of lncRNAs on the correlations betweenmethylationandmRNA. International Journal of Biochemistry & Cell Biology. 2018; 104:66-72.(IF: 3.144 ,II区)
57.Zhu H#, Wu LF#, Mo XB, Lu X, Tang H, Zhu XW, Xia W, Guo YF, Wang MJ, Zeng KQ, Wu J, Qiu YH, Lin X, Zhang YH, Liu YZ, Yi NJ, Deng FY*, Lei SF*. Rheumatoid Arthritis Associated DNA Methylation Sites in Peripheral Blood Mononuclear Cells. Ann Rheum Dis. 2019; 78(1):36-42. (IF: 19.1 , I 区)
58.Mo XB, Wu LF, Lu X, Zhu XW, Xia W, Wang L, He P, Bing PF, Zhang YH, Deng FY, Lei SF*. Detection of lncRNA-mRNA interaction modules by integrating eQTL with weighted gene co-expression network analysis. Functional & Integrative Genomics. 2019; 19(2):217-225. (IF: 3.058)
59.Wang BH, Lu YH, Xia W, Wu LF, Mo XB, Lu X, He P, Lei SF*. Distribution of single nucleotide polymorphism with a loss of heterozygosity status and its relevance on gene expression in Chinese Han. Journal of Biological Regulators & Homeostatic Agents. 2019; 33(4):1119-1124. (IF: 1.506)
60.Lu YH, Wang BH, Xia W, Mo XB, Wu LF, Zhang L, Zhu XW, He P, Lu X, Zhang YH, Deng FY*, Lei SF* Multi-omics Integrative Analysis Identified SNP-methylation-mRNA (SMM) Interaction Networks in Peripheral Blood Mononuclear Cells. J Cell Mol Med. 2019; 23:4601-4610. (IF: 5.31,II区)
61.Wang P, Huang L, Xu Q, Xu L, Deng FY, Lei SF*. Assessment of aortic stiffness in patients with rheumatoid arthritis using pulse wave velocity:anupdatemeta-analysis. ArchMedRes. 2019; 50(7):401-412. (IF: 2.23)
62.He P, Mo XB, Lei SF*, Deng FY*. Epigenetically regulated co-expression network of genes significant for rheumatoid arthritis. Epigenomics. 2019; 11(14):1601-1612. (IF: 4.778,II区)
63.Zhu XW#, Wu LF#, Mo XB, Xia W, Guo YF, Wang MJ, Zeng KQ, Wu J, Qiu YH, Lin X, Lu X, Deng FY*, Lei SF*. Identification of PBMC-ExpressedmiRNAs for Rheumatoid Arthritis. Epigenetics. 2020; 15(4):386-397. (IF: 4.528,II区)
64.Wu LF#, Wang WY#, Zhu DC, He P, Zhu K, Gui GP, Gao HQ, Mo XB, Lu X, Deng FY, Lei SF*. Protein array test detected three osteoporosis related plasma inflammatory cytokines in Chinese postmenopausal women. Cytokine. 2020; 133:155166. (IF: 3.861)
65.Mo XB, Sun YH, Zhang YH, Lei SF*. Integrative analysis highlighted susceptibility genes for rheumatoid arthritis. International Immunopharmacology. 2020; 86:106716. (IF: 4.932,II区)
66.Wang BH, Lu YH, Wu LF, Lu X, Guo W, Deng FY, Lei SF*. Evaluation of plasma cytokine protein array profile: the highlighted PDGF-BB in rheumatoid arthritis. Clin Rheumatol. 2020; 39(11):3323-3330. (IF: 2.98)
67.Huang L, Deng FY, Lei SF*. Global correlation analysis for miRNA and protein expression profiles in human peripheral blood mononuclear cells. Mol Biol Rep. 2020; 47(7):5295-5304.(IF: 2.316)
68.Mo XB#, Dong CY#, He P, Wu LF, Lu X, Zhang YH, Deng HW, Deng FY*, Lei SF*. Alteration of circulating microbiome and itsassociatedregulationrolein rheumatoid arthritis: Evidence from integration of multiomics data. Clinical Translational Medicine. 2020; 10:e229. (IF: 11.4, I 区)
69.Mo XB, Zhang YH, Lei SF*. Integrative analysis identifies potential causal methylation-mRNA regulation chains for rheumatoid arthritis. Molecular Immunology. 2021; 131: 89-96. (IF: 4.407)
70.Ge B#, Lu SQ#, Lei SF*. The obesity indices mediate therelationshipofbloodlipids and bone mineral density in Chinese. Molecular and Cellular Probes. 2021, 56:101705. (IF: 2.365）
71.Wu LF#, Mo XB#, He JH#, He P, Lu X, Deng HW, Deng FY*, Lei SF*. Integrative lncRNA-mRNA co-expression network analysis identifies novel lncRNA E2F3-IT1 for rheumatoid arthritis. Clinical Translational Medicine. 2021; 11:e325. (IF: 8.55, I 区)
72.Wang P, Liu L, Lei SF*.Causal effects of homocysteine levels on the changes of bone mineral density and risk for bone fracture: A two-sample Mendelian randomization study. Clinical Nutrition. 2021; 40:1588-1595. (IF: 7.64, I 区)
73.Wang P, Xu Q, Cao RR, Deng FY, Lei SF*. Global Public Interests and Dynamic Trends in Osteoporosis From2004 to 2019: Infodemiology Study. Journal of Medical Internet Research 2021;23(7):e25422. (IF: 7.076,II区)
74.Zhu DC#, Lu SQ#, Ge B, Lei SF*. Newly developed hip geometry parameters are associated with hip fracture.Journal of Orthopaedic Science 2021; 26:616-621. (IF: 1.8)
75.Yu XH, Wei YY, Zeng P*, Lei SF*. Birth weight is positively associated with adult osteoporosis risk: observational and Mendelian randomization studies. Journal ofBoneMineral Research. 2021; 36(8):1469–1480. (IF: 6.39，I 区)
76.Tang H, He JH, Gu HB, Zhu K, Lu CJ, Sun LL, Gui GP, Deng FY, Lei SF*. The different correlations between obesity and osteoporosis afteradjustmentofstaticmechanical loading from weight and fat free mass. Journal of MusculoskeletalandNeuronalInteractions. 2021 Sep 1;21(3):351-357. (IF: 1.86)
77.Yu XH, Yang YQ, Cao RR, Cai MK, Zhang L, Deng FY*, Lei SF*. Rheumatoid arthritis and osteoporosis:Sharedgeneticeffect, pleiotropy and causality. Hum Mol Genet. 2021;30(21):1932-1940. (IF:5.12，II区)
78.Cao RR#, He P#, Lei SF*. Novel microbiota-related gene set enrichment analysis identified osteoporosis associated gut microbiota from autoimmune diseases.JBoneMineral Metabolism. 2021 Nov;39(6):984-996. (IF:2.97)
79.Yu XH, Yang YQ, Cao RR, Bo L, Lei SF*. The Causal Role of Gut MicrobiotainDevelopment of Osteoarthritis. Osteoarthritis Cartilage. 2021; Osteoarthritis and Cartilage, 29(12): 1741-1750. (IF:7.5，小类I 区)
80.He P, Cao RR, Deng FY, Lei SF. Identification of Potential Pleiotropic Genes for Immune and Skeletal Diseases Using Multivariate MetaCCA Analysis. Current Genomics. 2021; 22(8): 596-606. (IF:2.68)
81.He P, Zhu H, Wu LF, Deng FY, Lei SF*. Response to 'Correspondence on 'Rheumatoid arthritis-associated DNA methylation sites in peripheral blood mononuclear cells ''by Wang and Niu. Ann Rheum Dis. 2022;81:e259.
82.Guan Y#, Lu YH#, Lei SF*. Physical activities mediate the correlations between serum creatinine and bone mineral density in Chinese. Clin Chim Acta. 2022; 524:25-33. (IF: 6.31, 小类II区)
83.He P, Deng FY*, Wang BH, Wu LF, Zhou X, Lei SF*. Epigenetically-regulated RPN2 gene influences lymphocyte activation and is involvedinpathogenesis of rheumatoid arthritis. Gene; 2022; 810:146059. (IF: 3.9)
84.Yu XH, Cao RR, Yang YQ, Lei SF*. Identification of causal metabolites related to multiple autoimmune diseases. Hum Mol Genet. 2022 Feb 21;31(4):604-613. (IF:5.12，II区)
85.Wu LF, Zhang Q, Mo XB, Lin J, Wu YL, Lu X, He P, Wu J, Guo YF, Wang MJ, Ren WY, Deng HW, Lei SF*, Deng FY*. Identification of novel rheumatoid arthritis-associatedMiRNA-204-5p from plasma exosomes. Experimental & Molecular Medicine. 2022 Mar;54(3):334-345. (IF: 12.1)
86.Yu XH, Bo L, Cao RR, Yang YQ, He P, Lei SF*, Deng FY*. Systematic Evaluation of Rheumatoid Arthritis Risk by Integrating Lifestyle Factors and Genetic Risk Scores. Front Immunol. 2022Jul6; 13:901223.(IF: 8.78)
87.Yu XH#, Cao RR#, Yang YQ, Zhang L, Lei SF*, Deng FY*. Systematic evaluation for the causal effects of blood metabolites on osteoporosis: Genetic risk score and Mendelian randomization. FrontPublicHealth. 2022Aug25; 10:905178. (IF: 6.46)
88.Yang YQ#, Yu XH#, Bo L, Lei SF*, Deng FY*. Genetic Risk for Osteoporosis andtheBenefitofAdherence to Healthy Lifestyles. International Journal of Public Health. 2022Sep 13; 67:1605114. (IF: 5.1,II区)
89.Cao RR#, Yu XH#1, Xiong MF, Li XT, Deng FY*, Lei SF*. The immune factors have complexcausalregulationeffectson bone mineral density. Front Immunol. 2022Oct20;13:959417.(IF: 8.78)
90.Xiong MF, Wu LF, Chen YH, Cao RR, Deng FY, Lei SF*. Body Surface Area (BSA) isaBetterOsteoporosisAssociatedAnthropometricParameterthanOtherAnthropometricParametersinElderlyPopulation. Journal of Clinical Densitometry. 2022; 25(4): 630-636.
91.Yu XH, Cao RR, Yang YQ, Deng FY, Bo L, Lei SF*. Body surface area (BSA) is a potential obesity index: its genetic determination and its causality for later-life diseases. Obesity 2023;31:256–266.
92.Yu XH#, Cao HW#, Bo L, Lei SF*, Deng FY*. Air Pollution, Genetic Factors and the Risk of Osteoporosis: A Prospective Study in the UK Biobank. Frontiers in Public Health. 2023; 11:1119774.
93.Sun LL#, Cao RR#, Wang JD#, Zhang GL, Deng FY, Lei SF*. Establishment of Reference Intervals for Bone Turnover Markers in Healthy Chinese Older Adults. 2023 Annals of Human Biology. 2023; 50(1):172–186.
94.Mo XB#, Sun YH#, Wu LF#, He P, Cao RR, Lu X, Zhang YH, Deng FY, Lei SF*. A novel long noncoding RNA, lnc-RNU12, influences the T-cell cycle via c-JUN and CCNL2 in rheumatoid arthritis. Rheumatology. 2023 May 2;62(5):1955-1963.
95.Wu JX, Deng FY, Lei SF*. The casual association inference for the chain of falls risk factors-falls-fallsoutcomes: a Mendelian randomization study. Healthcare. 2023; 11:1889.
96.Xiong MF, He P, Chen YH, Cao RR, Lei SF*. The effect of a body shape index (ABSI) and its interaction with low estimated glomerular filtration rate (eGFR) on osteoporosis in elderly Chinese. Journal of Orthopaedic Science. 2024；29：262-269.
97.Niu B, Wu JX, Huang XL, Lei SF*, Deng FY. Telomere length is a driving hallmark for aging-related biochemical hallmarks: evidence from the shared genetic effect and causal inference. J Gerontol A Biol Sci Med Sci. 2024 Apr 1;79(4):1-7.glad275.
98.Dan YL, Yang YQ, Zhu DC, Lin B, Lei SF*. Accelerated biological aging as a potential risk factor forrheumatoidarthritisInternational. Journal of Rheumatic Diseases 2024 Apr;27(4):e15156.
99.Fu T, Yang YQ, Tang CH, He P*, Lei SF*. Genetic Effects and Causal Associations of 14 Common Conditions/Diseases in Multimorbidity Patterns. PLoS ONE. 2024 May 16;19(5):e0300740.
100. He P*, Yang YQ, Wang H, Zhang YQian, Gu YN, Hong CC, Bo L, Deng FY and Lei SF*. Muscle-origin creatinine-cystatin C ratio is an osteoporosis marker in individuals with normal renal function: evidence from observational and Mendelian randomization analysis. Frontiers in Endocrinology. 2024; 15:1325320.
【科研获奖】
1.邓红文、谭丽君、陈湘定、雷署丰、邓飞艳、张丽姝。湖南省自然科学奖二等奖，2015.12
2.邓红文、陈湘定、莫小阳、刘曼媛、雷署丰、刘湘华，2003 年度湖南省科学技术进步奖二等奖（2003-230-065）
3.邓红文、邓飞艳、张圆圆、谭远德、雷署丰，教育部提名国家科学技术奖自然科学奖二等奖 2004.12
4.雷署丰,国际骨质疏松高级研讨会 2003 IOC 优秀青年学者奖三等奖 2003.10
【科研项目】
1.国家自然科学基金面上项目，82373587，外泌体介导的神经调节与绝经后妇女骨质疏松症的关联评价及其机制研究，49万，2024.01-2027.12，主持人。
国家自然基金面上项目，82173529，单细胞测序技术解析免疫细胞在绝经后妇女骨质疏松症中的细胞与分子致病机制研究，55万，2022.01-2025.12，主持人。
2.国家自然科学基金面上项目，81872681，血浆细胞因子CXCL13作为骨质疏松性骨折风险生物标志物的评价与应用研究，57万，2019.01-2022.12，主持人。
3.国家自然科学基金面上项目，81473046，类风湿性关节炎相关miRNA的鉴定以及血浆miRNA标志物的筛选与评价研究，80万，2015.1-2018.12，主持人。
4.国家自然科学基金面上项目，31271336，启动子区域遗传多态性位点与骨质疏松关联机制研究，81万，2013.1-2016.12，主持人。
5.国家自然科学基金面上项目，31071097，miRNA靶位点遗传多态性调控骨质疏松机理研究，36万，2011.1-2013.12，主持人。
6.国家自然科学基金国际合作项目--中加（NSFC-CIHR）健康研究合作计划，30811120436，中国和加拿大人群中肥胖基因的研究：重复性的证据与种族和性别差异的研究，45万，2009.1-2011.12，中方主持人。
7.国家自然科学基金青年基金项目，30600364，高低尾峰值骨量组间破骨细胞前体的差异表达蛋白的验证与鉴定，21万，2007.1-2009.12，主持人。
苏州大学人才引进启动基金，Q41390112，400万，2012-2017，主持人。
【联系方式】
联系电话：0512-65883357, E-mail：leisf@suda.edu.cn，
欢迎具有各学科（预防医学、数学、统计学、计算机科学和遗传学等）背景的有志青年报考本课题组的研究生。